DIABETES ELEVATES LEVELS OF SYSTEMIC INFLAMMATION....
Systemic inflammation is believed to play an important role in the development of type 2 diabetes. Evidence points to an increased cytokine response in type 2 diabetes, especially the pro-inflammatory proteins/cytokines (i.e. IL-1 beta, IL-6, and tumor necrosis factor-alpha). Tumor necrosis factor-α (TNF-α) may play an important role in insulin resistance (1). Porphyromonas gingivalis, one of the microorganisms responsible for this infection, is able to invade endothelial cells and is a potent signal for monocyte and macrophage activation.Once established in the diabetic host, chronic periodontal infections complicate diabetes control and increases the occurrence and severity of microvascular and macrovascular complications (2). The medical literature supports the idea that treatment of chronic oral infections is essential in people with diabetes. Antimicrobial therapy significantly reduced the number of microorganisms in periodontal pockets. The results indicate that anti-infectious treatment is effective in improving metabolic control in diabetics, possibly through reduced serum TNF-α and improved insulin resistance (3).Physicians managing diabetic conditions in their patients should consider assessment of oral infection status to be fundamental for appropriate treatment decisions.
1- Iwamoto Y, Nishimura F., The Effect of Antimicrobial Periodontal Treatment on Circulating Tumor Necrosis Factor-Alpha and Glycated Hemoglobin Level in Patients With Type 2 Diabetes. J Periodontol 2001;72:774-778.2- Grossi SG. Treatment of Periodontal Disease and Control of Diabetes: An Assessment of the Evidence and Need for Future Research. Annals of Periodontology 2001, Vol. 6, No. 1, Pages 138-145.3- Ibid, Iwamoto
1- Iwamoto Y, Nishimura F., The Effect of Antimicrobial Periodontal Treatment on Circulating Tumor Necrosis Factor-Alpha and Glycated Hemoglobin Level in Patients With Type 2 Diabetes. J Periodontol 2001;72:774-778.2- Grossi SG. Treatment of Periodontal Disease and Control of Diabetes: An Assessment of the Evidence and Need for Future Research. Annals of Periodontology 2001, Vol. 6, No. 1, Pages 138-145.3- Ibid, Iwamoto